Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophy
Identifieur interne : 001130 ( Main/Exploration ); précédent : 001129; suivant : 001131Abnormal responses to repetitive transcranial magnetic stimulation in multiple system atrophy
Auteurs : Wolfgang N. Löscher [Autriche] ; Michaela Stampfer-Kountchev [Autriche] ; Martin Sawires [Autriche] ; Klaus Seppi [Autriche] ; Joerg Mueller [Autriche] ; Christoph Szubski [Autriche] ; Katrin Hirnsperger [Autriche] ; Christian Brenneis [Autriche] ; Werner Poewe [Autriche] ; Gregor K. Wenning [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-01-15.
English descriptors
Abstract
We studied the response of the motor cortex to brief trains of suprathreshold repetitive transcranial magnetic stimulations (rTMS) in patients with the Parkinson‐variant of multiple system atrophy (MSA‐P) and compared it to patients with idiopathic Parkinson's disease (PD) and healthy controls. Eight subjects were studied in each group, and patients were matched for disease severity as assessed by Hoehn & Yahr stages. rTMS was delivered at rest and during low‐level contractions in trains of 10 stimulations at 5 Hz, and stimulation intensity was set to result in an motor evoked potential (MEP) in the first dorsal interosseus muscle of 0.5 to 1.0 mV. In MSA‐P, MEP amplitude at rest was already reduced after the second stimulus and remained so, while it did not change in PD and controls. During contraction, MEP size did not change during the train in any group. The silent period that followed the last stimulus was of similar duration as the first stimulus in MSA‐P, but was increased in PD and controls. These findings indicate that abnormal inhibition occurs within the motor cortex in MSA‐P, despite dopaminergic treatment and indicate differences in cortical dysfunction between MSA‐P and PD. We suggest that these abnormalities reflect the motor cortex pathology found in MSA‐P. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21242
Affiliations:
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Eight subjects were studied in each group, and patients were matched for disease severity as assessed by Hoehn & Yahr stages. rTMS was delivered at rest and during low‐level contractions in trains of 10 stimulations at 5 Hz, and stimulation intensity was set to result in an motor evoked potential (MEP) in the first dorsal interosseus muscle of 0.5 to 1.0 mV. In MSA‐P, MEP amplitude at rest was already reduced after the second stimulus and remained so, while it did not change in PD and controls. During contraction, MEP size did not change during the train in any group. The silent period that followed the last stimulus was of similar duration as the first stimulus in MSA‐P, but was increased in PD and controls. These findings indicate that abnormal inhibition occurs within the motor cortex in MSA‐P, despite dopaminergic treatment and indicate differences in cortical dysfunction between MSA‐P and PD. We suggest that these abnormalities reflect the motor cortex pathology found in MSA‐P. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Loscher, Wolfgang N" sort="Loscher, Wolfgang N" uniqKey="Loscher W" first="Wolfgang N." last="Löscher">Wolfgang N. Löscher</name></noRegion><name sortKey="Brenneis, Christian" sort="Brenneis, Christian" uniqKey="Brenneis C" first="Christian" last="Brenneis">Christian Brenneis</name><name sortKey="Hirnsperger, Katrin" sort="Hirnsperger, Katrin" uniqKey="Hirnsperger K" first="Katrin" last="Hirnsperger">Katrin Hirnsperger</name><name sortKey="Mueller, Joerg" sort="Mueller, Joerg" uniqKey="Mueller J" first="Joerg" last="Mueller">Joerg Mueller</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Sawires, Martin" sort="Sawires, Martin" uniqKey="Sawires M" first="Martin" last="Sawires">Martin Sawires</name><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name><name sortKey="Stampfer Ountchev, Michaela" sort="Stampfer Ountchev, Michaela" uniqKey="Stampfer Ountchev M" first="Michaela" last="Stampfer-Kountchev">Michaela Stampfer-Kountchev</name><name sortKey="Szubski, Christoph" sort="Szubski, Christoph" uniqKey="Szubski C" first="Christoph" last="Szubski">Christoph Szubski</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. 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